Invention Grant
US09255274B2 Protein-responsive translational regulatory system using RNA-protein interacting motif
有权
蛋白质反应的翻译调节系统使用RNA蛋白相互作用的主题
- Patent Title: Protein-responsive translational regulatory system using RNA-protein interacting motif
- Patent Title (中): 蛋白质反应的翻译调节系统使用RNA蛋白相互作用的主题
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Application No.: US12743853Application Date: 2008-11-21
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Publication No.: US09255274B2Publication Date: 2016-02-09
- Inventor: Tan Inoue , Hirohide Saito , Tetsuhiro Kobayashi , Tomoaki Hara
- Applicant: Tan Inoue , Hirohide Saito , Tetsuhiro Kobayashi , Tomoaki Hara
- Applicant Address: JP Saitama
- Assignee: Japan Science and Technology Agency
- Current Assignee: Japan Science and Technology Agency
- Current Assignee Address: JP Saitama
- Agency: Meunier Carlin & Curfman LLC
- Priority: JP2007-303662 20071122; JP2008-186385 20080717
- International Application: PCT/JP2008/071213 WO 20081121
- International Announcement: WO2009/066757 WO 20090528
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12P21/06 ; C12N15/67
Abstract:
An object of the present invention is to provide a translationally regulatable mRNA which has wider application and can perform specific ON-OFF regulation, an RNA-protein complex specifically bound to the mRNA, and a translational regulatory system. The present invention provides an mRNA having an RNA-protein complex interacting motif-derived nucleotide sequence 5′ to the ribosome-binding site or within the 5′ region of the open reading frame, and an mRNA having a nucleotide sequence complementary to an RNA-protein complex interacting motif-derived nucleotide sequence 5′ to the ribosome-binding site or within the 5′ region of the open reading frame.
Public/Granted literature
- US20110040077A1 Protein-Responsive Translational Regulatory System Using RNA-Protein Interacting Motif Public/Granted day:2011-02-17
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