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US09255298B2 Probe, and polymorphism detection method using the same 有权
探针和多态性检测方法使用相同

  • Patent Title: Probe, and polymorphism detection method using the same
  • Patent Title (中): 探针和多态性检测方法使用相同
  • Application No.: US13863877
    Application Date: 2013-04-16
  • Publication No.: US09255298B2
    Publication Date: 2016-02-09
  • Inventor: Moeko Ijuin
  • Applicant: Moeko Ijuin
  • Applicant Address: JP Kyoto
  • Assignee: ARKRAY, Inc.
  • Current Assignee: ARKRAY, Inc.
  • Current Assignee Address: JP Kyoto
  • Agency: Morgan, Lewis & Bockius LLP
  • Priority: JP2012-096558 20120420; JP2013-081858 20130410
  • Main IPC: C12Q1/68
  • IPC: C12Q1/68 ;  C12P19/34
Probe, and polymorphism detection method using the same
Abstract:
The present invention provides a probe for detecting a V600 polymorphism in the BRAF gene, which is (P1) a fluorescently labeled oligonucleotide which has an identity of at least 80% to a base sequence having a length of 10 to 50 bases including the 228th to the 237th bases of the base sequence indicated in SEQ ID NO: 1, wherein the base corresponding to the 237th base is cytosine labeled with a fluorescent dye, the oligonucleotide recognizing a polymorphism in at least one of the 228th to the 230th bases of the base sequence indicated in SEQ ID NO: 1 (with the proviso that the oligonucleotide is not the one indicated in SEQ ID NO: 7 or 19).
Abstract(Chinese):

本发明提供了一种用于检测BRAF基因中的V600多态性的探针，其是（P1）荧光标记的寡核苷酸，其与长度为10至50个碱基的碱基序列具有至少80％的同一性，包括228位至 SEQ ID NO：1所示的碱基序列的第237个碱基，其中对应于第237碱基的碱基是用荧光染料标记的胞嘧啶，所述寡核苷酸识别碱基的第228位至第230位碱基中的至少一个的多态性 SEQ ID NO：1所示的序列（条件是寡核苷酸不是SEQ ID NO：7或19所示的序列）。

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