Invention Grant
US09255348B2 Systems and methods for biodosimetry with biochip using gene expression signatures
有权
使用基因表达特征的生物芯片生物测定法的系统和方法
- Patent Title: Systems and methods for biodosimetry with biochip using gene expression signatures
- Patent Title (中): 使用基因表达特征的生物芯片生物测定法的系统和方法
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Application No.: US12438944Application Date: 2007-08-24
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Publication No.: US09255348B2Publication Date: 2016-02-09
- Inventor: Frederic Zenhausern , Christine Orozco , Mark Richards , Carl Yamashiro , Sally A. Amundson , Ralf Lenigk , Michael L. Bittner , Yoganand Balagurunathan
- Applicant: Frederic Zenhausern , Christine Orozco , Mark Richards , Carl Yamashiro , Sally A. Amundson , Ralf Lenigk , Michael L. Bittner , Yoganand Balagurunathan
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Dentons US LLP
- International Application: PCT/US2007/076802 WO 20070824
- International Announcement: WO2008/082712 WO 20080710
- Main IPC: C12M1/34
- IPC: C12M1/34 ; C40B60/12 ; B01L3/00 ; C40B30/10 ; G01T1/02
Abstract:
Exposure to ionizing radiation can produce a well-defined dose dependent signature in terms of changes in gene expression. In approaches and devices described herein, such a signature can be used to generate and use a self-contained radiation biodosimeter device, based on, for example, a blood finger stick. Various aspects of the invention are directed to biodosimetry with a fully integrated biochip using gene expression signatures.
Public/Granted literature
- US20100144558A1 SYSTEMS AND METHODS FOR BIODOSIMETRY WITH BIOCHIP USING GENE EXPRESSION SIGNATURES Public/Granted day:2010-06-10
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