Invention Grant
US09255933B2 Imaging beta-amyloid peptides and inhibition of beta-amyloid peptide aggregation
有权
成像β-淀粉样蛋白肽和β-淀粉样肽聚集的抑制
- Patent Title: Imaging beta-amyloid peptides and inhibition of beta-amyloid peptide aggregation
- Patent Title (中): 成像β-淀粉样蛋白肽和β-淀粉样肽聚集的抑制
-
Application No.: US14231715Application Date: 2014-03-31
-
Publication No.: US09255933B2Publication Date: 2016-02-09
- Inventor: Lei Guo , Di Xu , See-Lok Ho , Chung-Yan Poon , Olivia T. W. Ng , Hung Wing Li , Ken K. L. Yung , Daniel W. J. Kwong , Ricky M. S. Wong
- Applicant: Hong Kong Baptist University
- Applicant Address: HK Kowloon Tong, Kowloon
- Assignee: HONG KONG BAPTIST UNIVERSITY
- Current Assignee: HONG KONG BAPTIST UNIVERSITY
- Current Assignee Address: HK Kowloon Tong, Kowloon
- Agency: Ella Cheong Hong Kong
- Agent Sam T. Yip
- Main IPC: A61K49/10
- IPC: A61K49/10 ; A61K49/00 ; G01N33/68 ; A61K49/08 ; C07D401/06 ; A61B5/00 ; A61B5/055 ; G01R33/56
Abstract:
The present invention is in the field of pharmaceuticals and chemical industries. In particular, the present invention relates to methods for labeling, imaging and detecting the beta-amyloid (Aβ) peptides, oligomers, and fibrils in vitro by using carbazole-based fluorophores. A further aspect of the present invention relates to a method of reducing and preventing aggregation of beta-amyloid peptides for Alzheimer's disease (AD) as well as of treating and/or preventing Alzheimer's disease by using carbazole-based fluorophores.
Public/Granted literature
- US20140212360A1 Imaging Beta-Amyloid Peptides and Inhibition of Beta-Amyloid Peptide Aggregation Public/Granted day:2014-07-31
Information query
