Generalized state-dependent learning framework in artificial neuron networks may be implemented. A framework may be used to describe plasticity updates of neuron connections based on connection state term and neuron state term. The state connections within the network may be updated based on inputs and outputs to/from neurons. The input connections of a neuron may be updated using connection traces comprising a time-history of inputs provided via the connections. Weights of the connections may be updated and connection state may be time varying. The updated weights may be determined using a rate of change of the trace and a term comprising a product of a per-neuron contribution and a per-connection contribution configured to account for the state time-dependency. Using event-dependent connection change components, connection updates may be executed on per neuron basis, as opposed to per-connection basis.