Application programs delivered from one or more cloud computing systems (“clouds” or “CCSs”) are integrated into a desktop being delivered/hosted by another cloud (“primary” CCS). In one respect, the integration includes integration of controls for directly launching a separately hosted application program from a desktop hosted by the primary CCS, such as by selection of a start menu entry or activation of a “shortcut” icon that points to the application program. In another respect, a separately hosted application program is launched based on a user opening or accessing content (e.g. data file) that is specifically associated with the separately hosted application program but residing more locally, such as in the hosted desktop. In this aspect, the content is seamlessly redirected to the other cloud without requiring any direct network connectivity between the clouds.