A user selection of an item corresponding to a Web page can be received. The user selection can represents a request to open the Web page within an instantiated one of a set of Web browser applications installed on a computing device. A set of Web page elements unique to the Web page can be identified through an analysis conducted by the computing device. The identified set of Web page elements can be utilized to determine at the computing device one of the installed Web browser applications for the Web page. The determination of the one installed Web browser application can varies from Web page-to-Web page. At the computing device, the determined one of the Web browser applications can be instantiated. The Web page can be opened within the instantiated one of the Web browser applications.