A method, system and computer-readable medium for reducing repeater power and crosstalk are provided. The method includes generating a model of a circuit including a plurality of original repeaters connected between at least one source and at least one sink, performing a power optimization analysis on the plurality of original repeaters to change the plurality of original repeaters to low-power repeaters based on predetermined optimization parameters, performing a crosstalk analysis on the model of the circuit including the low-power repeaters to determine whether a crosstalk timing violation exists, and changing at least one of the low-power repeaters to a higher-power repeater when it is determined that a crosstalk violation exists, and leaving the low-power repeaters in the model of the circuit when it is determined that a crosstalk violation does not exist.