Certain methods and systems are described that allow the spectral control of a print output. A plurality of colorants are used where one or more colorants contain nanoparticles. Each colorants has a specified spectral range corresponding to the constituent nanoparticles. To print with these colorants a spectral separation may be used that maps an input color with associated spectral information or direct spectral information to print control data, the print control data having defined values for depositions with each combination of the colorants. The spectral separation may be constructed by characterizing a set of spectral Neugebauer primaries for the plurality of colorants.