Disclosed herein are techniques for translating a first image of a first type to a derived image of a second type. For example, a plurality of similarity indicators can be computed as between a plurality of patches of first image and a plurality of patches of a first atlas image, the first atlas image being of the first type. Weight factors can then be computed based on the computed similarity indicators. These weight factors can be applied to a plurality of data points of a second atlas image to compute a plurality of data points for the derived image such that each of at least a plurality of the data points for the derived image is a function of a plurality of the data points of the second atlas image. Such a technique can be used for pseudo-CT generation from an MR image.