Components, systems, and methods for reducing location-based interference in distributed antenna systems operating in multiple-input, multiple-output (MIMO) configuration are disclosed. Interference is defined as issues with received MIMO communications signals that can cause a MIMO algorithm to not be able to solve a channel matrix for MIMO communications signals received by MIMO receivers in client devices. These issues may be caused by lack of spatial (i.e., phase) separation in the received MIMO communications signals. Thus, to provide phase separation of received MIMO communication signals, multiple MIMO transmitters are each configured to employ multiple transmitter antennas, which are each configured to transmit in different polarization states. In certain embodiments, one of the MIMO communications signals is phase shifted in one of the polarization states to provide phase separation between received MIMO communication signals. In other embodiments, multiple transmitter antennas in a MIMO transmitter can be offset to provide phase separation.