A therapy system (10) includes one or more processors (98, 100). The processors (98, 100) are programmed to receive one or more of: (1) dosimetric data from dosimeters (26, 28, 202, 204, 206, 208, 210, 212) implanted within a patient and/or positioned on a vest (200); and (2) motion data from surrogates (18, 20, 22, 24) implanted within the patient. Based on the motion data, a current location and/or shape of a surrogate (18, 20, 22, 24) is determined and deviations between the current location and/or shape and a reference location and/or shape are determined. Based on the dosimetric data, a delivered dose distribution is compared with a planned dose distribution and deviations therebetween are determined. The deviations determined from the motion data and/or the dosimetric data are employed for adaptive planning, alignment, post treatment analysis, and safety.