Invention Grant
US09259396B2 Method of preparing soy isoflavone nanoparticles by precipitation with compressed antisolvent (PCA) using a supercritical fluid
有权
使用超临界流体通过用压缩抗溶剂（PCA）沉淀制备大豆异黄酮纳米颗粒的方法
- Patent Title: Method of preparing soy isoflavone nanoparticles by precipitation with compressed antisolvent (PCA) using a supercritical fluid
- Patent Title (中): 使用超临界流体通过用压缩抗溶剂（PCA）沉淀制备大豆异黄酮纳米颗粒的方法
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Application No.: US13733901Application Date: 2013-01-04
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Publication No.: US09259396B2Publication Date: 2016-02-16
- Inventor: Kathy Qian Luo , Jinjie Xu
- Applicant: Nano and Advanced Materials Institute Limited
- Applicant Address: HK Hong Kong
- Assignee: NANO AND ADVANCED MATERIALS INSTITUTE LIMITED
- Current Assignee: NANO AND ADVANCED MATERIALS INSTITUTE LIMITED
- Current Assignee Address: HK Hong Kong
- Agent Ella Cheong Hong Kong; Sam T. Yip
- Main IPC: A61K31/352
- IPC: A61K31/352 ; A61K9/51 ; C07D311/36 ; A61K9/00
Abstract:
The present invention relates to a method of preparing a solid form of soy isoflavone (e.g. genistein). In particular, the present invention relates to a method of preparing a solid form of soy isoflavone by precipitation with compressed antisolvent using a supercritical fluid to produce nano-sized particles of soy isoflavone with an improved dissolution rate and bioavailability. An oral composition or aerosolized formulation comprising the nanoparticles of the soy isoflavone prepared by the method of the present invention is also disclosed herein. The dissolution rate and bioavailability of the nanoparticles of the soy isoflavone prepared by the method of the present invention have a 2-fold increase and a 2.6-fold increase respectively as compared to those of the raw soy isoflavone.
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