Invention Grant
- Patent Title: Class of diazepine derivative chelating agents and complexes with paramagnetic metals thereof as MRI contrast agents
- Patent Title (中): 二氮杂衍生物螯合剂类及其顺磁金属络合物作为MRI造影剂
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Application No.: US14384414Application Date: 2013-03-13
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Publication No.: US09259491B2Publication Date: 2016-02-16
- Inventor: Lorena Beltrami , Luciano Lattuada , Alessandro Maiocchi , Massimo Visigalli , Loredana Sini
- Applicant: BRACCO IMAGING S.P.A.
- Applicant Address: IT Milan
- Assignee: Bracco Imaging S.P.A.
- Current Assignee: Bracco Imaging S.P.A.
- Current Assignee Address: IT Milan
- Agency: VIVICAR Law, PLLC
- Priority: EP12159378 20120314
- International Application: PCT/EP2013/055094 WO 20130313
- International Announcement: WO2013/135750 WO 20130919
- Main IPC: C07D243/08
- IPC: C07D243/08 ; C07F9/645 ; A61K49/10
Abstract:
The present invention relates to a new class of diazepine-derivatives as chelating agents for paramagnetic metal ions, the process for their preparation, and use of such paramagnetic complexes as contrast agents, particularly suitable for Magnetic Resonance Imaging (MRI) analysis. The present invention refers to a new class of derivatives of formula (I), or a pharmaceutically acceptable salt thereof.
Public/Granted literature
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