The present invention relates to a dialysis machine for the purification of blood, a manifold for the dialysis machine as well as to a process for the regeneration of the dialysis bath. It is an object of the present invention to provide a dialysis machine, a manifold for the dialysis machine as well a process which facilitates the administration of medical preparations during a dialysis procedure. In order to solve the object, a dialysis machine according to the present invention comprises tubes (1, 5, 8) connected with a dialyzer (6), means for delivering pharmaceuticals into the tubes and a pump (11) for the transport of blood through the tubes and the dialyzer. The dialysis machine comprises means for administration (4) of at least one pharmaceutical by a suction effect of the pump or by a pressure effect of the pump or by an excess pressure of a gas or a liquid.