Invention Grant
- Patent Title: Method for production of chromatography media
- Patent Title (中): 色谱介质的制备方法
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Application No.: US13642937Application Date: 2011-04-20
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Publication No.: US09259729B2Publication Date: 2016-02-16
- Inventor: Jan Bergstrom , Bo-Lennart Johansson
- Applicant: Jan Bergstrom , Bo-Lennart Johansson
- Applicant Address: SE Uppsala
- Assignee: GE Healthcare Bio-Sciences AB
- Current Assignee: GE Healthcare Bio-Sciences AB
- Current Assignee Address: SE Uppsala
- Agency: Parks Wood LLC
- Agent Collen A. Beard, Esq.
- Priority: SE1050407 20100426
- International Application: PCT/SE2011/050481 WO 20110420
- International Announcement: WO2011/136721 WO 20111103
- Main IPC: B01J39/16
- IPC: B01J39/16 ; B01J47/00 ; B01J20/286 ; B01J20/32 ; B01J20/28

Abstract:
The present invention relates to a method and means to produce chromatography media having improved pressure-flow properties. More closely, the invention relates to bimodal particle size distribution and the use of layer functionalization as means to change pressure-flow properties of chromatography media. The invention relates to a method for production of chromatography media having improved pressure-flow properties, comprising mixing large beads/particles, comprising an inner core and an outer functionalized shell/lid, with smaller beads/particles, wherein the ratio of the particle size of large and small beads: [D50V for large particles/D50V for small particles]>1.2, and wherein the volume ratio of large and small beads in the column: [Total volume of large beads/Total volume beads] is in the range 0.05-0.9.
Public/Granted literature
- US20130040809A1 METHOD FOR PRODUCTION OF CHROMATOGRAPHY MEDIA Public/Granted day:2013-02-14
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