Disclosed is a center reinforcement structure of a panoramic sunroof that is coupled in a vehicle width direction between a front glass and a rear glass disposed at a ceiling of a vehicle. The center reinforcement structure may include a frame which is disposed in the vehicle width direction, and has one end that is tightly attached and fixedly coupled to a lower portion of the rear glass, and a first center reinforcement which is coupled to a lower portion of the frame, and has a first closed cross-sectional portion that is formed at one side of the first center reinforcement by sequentially bending a first plate to provide a first closed space, and a first joint portion that is formed at the other side of the first center reinforcement by overlapping both ends of the first plate substantially in parallel so that both ends of the first plate are in surface contact with each other.