Invention Grant
- Patent Title: Metallo-β-lactamase inhibitors
- Patent Title (中): 金属和β-内酰胺酶抑制剂
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Application No.: US13306372Application Date: 2011-11-29
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Publication No.: US09260375B2Publication Date: 2016-02-16
- Inventor: Ken Chikauchi , Mizuyo Ida , Takao Abe , Yukiko Hiraiwa , Akihiro Morinaka , Toshiaki Kudo
- Applicant: Ken Chikauchi , Mizuyo Ida , Takao Abe , Yukiko Hiraiwa , Akihiro Morinaka , Toshiaki Kudo
- Applicant Address: JP Tokyo-To
- Assignee: Meiji Seika Kaisha, Ltd.
- Current Assignee: Meiji Seika Kaisha, Ltd.
- Current Assignee Address: JP Tokyo-To
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2005-275487 20050922
- Main IPC: C07C57/02
- IPC: C07C57/02 ; A61K31/43 ; A61K31/397 ; A61K31/00 ; C07C69/593 ; A61K31/194 ; C07C57/145 ; A61K31/445 ; A61K31/495 ; A61K31/5375 ; A61K45/06 ; C07C51/00 ; C07C57/13 ; C07C57/26 ; C07C57/42 ; C07C57/50 ; C07C59/52 ; C07C59/64 ; C07C59/70 ; C07C69/618 ; C07C69/734 ; C07C217/22 ; C07C233/65 ; C07C235/20 ; C07C237/22 ; C07C279/08 ; C07C323/54 ; C07D211/46 ; C07D211/60 ; C07D213/80 ; C07D295/192 ; C07D309/06 ; A61K31/407 ; A61K31/546
Abstract:
A new metallo-β-lactamase inhibitor which acts as a medicament for inhibiting the inactivation of β-lactam antibiotics and recovering anti-bacterial activities is disclosed. The maleic acid derivatives having the general formula (I) have metallo-β-lactamase inhibiting activities. It is possible to recover the anti-bacterial activities of β-lactam antibiotics against metallo-β-lactamase producing bacteria by combining the compound of the general formula (I) with β-lactam antibiotics.
Public/Granted literature
- US20120071457A1 METALLO-BETA-LACTAMASE INHIBITORS Public/Granted day:2012-03-22
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