Invention Grant
US09260394B2 Derivatives of nicotinic acid N-oxide, their preparation and their use as inhibitors of enzyme 3-hydroxyanthranilate-3, 4-dioxygenase
有权
烟酸N-氧化物的衍生物，其制备及其作为3-羟基邻氨基苯甲酸酯-3,4-二加氧酶酶抑制剂的用途
- Patent Title: Derivatives of nicotinic acid N-oxide, their preparation and their use as inhibitors of enzyme 3-hydroxyanthranilate-3, 4-dioxygenase
- Patent Title (中): 烟酸N-氧化物的衍生物，其制备及其作为3-羟基邻氨基苯甲酸酯-3,4-二加氧酶酶抑制剂的用途
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Application No.: US13979517Application Date: 2011-01-19
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Publication No.: US09260394B2Publication Date: 2016-02-16
- Inventor: Robert Schwarcz , Gabriele Costantino , Laura Amori
- Applicant: Robert Schwarcz , Gabriele Costantino , Laura Amori
- Applicant Address: US MD Baltimore IT
- Assignee: UNIVERSITY OF MARYLAND, BALTIMORE,UNIVERSITA' DELGI STUDI DI PARMA
- Current Assignee: UNIVERSITY OF MARYLAND, BALTIMORE,UNIVERSITA' DELGI STUDI DI PARMA
- Current Assignee Address: US MD Baltimore IT
- Agency: Moore & Van Allen, PLLC
- Agent Marianne Fulerer
- International Application: PCT/EP2011/050670 WO 20110119
- International Announcement: WO2012/097869 WO 20120726
- Main IPC: C07D213/89
- IPC: C07D213/89 ; A61K31/455
Abstract:
A derivative of nicotinic acid N-oxide is described having formula (I): that acts as inhibitor of enzyme 3-hydroxyanthranilate-3,4-dioxygenase (3HAO), and is thus able to reduce QUIN biosynthesis in vivo under excitotoxic or pathological conditions, said compound being at the same time also chemically stable towards auto-oxidation.
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