Invention Grant
US09260418B2 Pyranyl aryl methyl benzoquinolinone M1 receptor positive allosteric modulators
有权
吡喃基芳基甲基苯并喹啉酮M1受体正变构调节剂
- Patent Title: Pyranyl aryl methyl benzoquinolinone M1 receptor positive allosteric modulators
- Patent Title (中): 吡喃基芳基甲基苯并喹啉酮M1受体正变构调节剂
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Application No.: US14470080Application Date: 2014-08-27
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Publication No.: US09260418B2Publication Date: 2016-02-16
- Inventor: Scott D. Kuduk , Ronald K. Chang , Thomas J. Greshock
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sylvia A. Ayler; John C. Todaro
- Main IPC: A61K31/517
- IPC: A61K31/517 ; C07D405/04 ; A61K31/535 ; C07D471/04 ; C07D473/00 ; C07D487/02 ; C07D495/04 ; C07D401/14 ; C07D405/14 ; C07D409/14 ; C07D417/14 ; C07D491/056 ; C07F7/08
Abstract:
The present invention is directed to pyranyl aryl methyl benzoquinazolinone compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which the M1 receptor is involved, such as Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.
Public/Granted literature
- US20140364395A1 Pyranyl Aryl Methyl Benzoquinolinone M1 Receptor Positive Allosteric Modulators Public/Granted day:2014-12-11
Information query
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