Invention Grant
US09260428B2 Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
有权
用于合成8 - [{1-（3,5-双 - （三氟甲基）苯基） - 乙氧基} - 甲基] -8-苯基-1,7-二氮杂 - 螺[4.5]癸-2-醇的方法和中间体 一种化合物
![Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds](/docs/US/2016-02-16/US09260428B2/abs.jpg.600x600.jpg)
- Patent Title: Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds
- Patent Title (中): 用于合成8 - [{1-（3,5-双 - （三氟甲基）苯基） - 乙氧基} - 甲基] -8-苯基-1,7-二氮杂 - 螺[4.5]癸-2-醇的方法和中间体 一种化合物
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Application No.: US14039367Application Date: 2013-09-27
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Publication No.: US09260428B2Publication Date: 2016-02-16
- Inventor: Ingrid Mergelsberg , Dominik Hermann Scherer , Monika Erika Huttenloch , Hon-Chung Tsui , Sunil Paliwal , Neng-Yang Shih
- Applicant: OPKO HEALTH, INC.
- Applicant Address: US FL Miami
- Assignee: OPKO Health, Inc.
- Current Assignee: OPKO Health, Inc.
- Current Assignee Address: US FL Miami
- Agency: Choate, Hall & Stewart LLP
- Agent Brenda Herschbach Jarrell; Kristen C. Buteau
- Main IPC: C07D221/00
- IPC: C07D221/00 ; C07D471/10 ; C07D211/38 ; C07D498/10 ; C07D211/56
![Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds](/abs-image/US/2016/02/16/US09260428B2/abs.jpg.150x150.jpg)
Abstract:
This application discloses a process to synthesize 8-({1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-pheny-1.7-diaza-spiro[4.5]decan-2-one comprising reacting a compound of the Formula 27a-sulfonate with zinc in the presence of acetic acid.
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