Invention Grant
US09260492B2 Muteins of human lipocalin 2 with affinity for glypican-3 (GPC-3)
有权
具有亲和性的磷脂酰肌醇蛋白聚糖3（GPC-3）的人脂质运载蛋白2的突变蛋白
- Patent Title: Muteins of human lipocalin 2 with affinity for glypican-3 (GPC-3)
- Patent Title (中): 具有亲和性的磷脂酰肌醇蛋白聚糖3（GPC-3）的人脂质运载蛋白2的突变蛋白
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Application No.: US13885229Application Date: 2011-11-15
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Publication No.: US09260492B2Publication Date: 2016-02-16
- Inventor: Gabriele Matschiner , Andreas Hohlbaum , Kristian Jensen
- Applicant: Gabriele Matschiner , Andreas Hohlbaum , Kristian Jensen
- Applicant Address: DE Freising-Weihenstephan
- Assignee: Pieris AG
- Current Assignee: Pieris AG
- Current Assignee Address: DE Freising-Weihenstephan
- Agency: Foley & Lardner LLP
- Priority: EP10191228 20101115
- International Application: PCT/EP2011/070119 WO 20111115
- International Announcement: WO2012/065978 WO 20120524
- Main IPC: C07K14/435
- IPC: C07K14/435 ; C12N9/96 ; C07K16/44 ; A61K38/00 ; C07K14/47 ; C07K16/00 ; C12P21/08
Abstract:
Described are specific-binding therapeutic and/or diagnostic proteins directed against Glypican-3 (GPC3), which proteins include muteins of a lipocalin protein, such as lipocalin 2 (Lcn2 or NGAL). The invention also relates to nucleic acid molecules encoding such proteins and to methods for generation and use of such proteins and nucleic acid molecules. Accordingly, the invention also is directed to pharmaceutical and/or diagnostic compositions comprising such lipocalin proteins, including uses of these proteins.
Public/Granted literature
- US20130296258A1 MUTEINS OF HUMAN LIPOCALIN 2 WITH AFFINITY FOR GLYPICAN-3 (GPC-3) Public/Granted day:2013-11-07
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