Invention Grant
- Patent Title: Methods for screening for binding partners of G-protein coupled receptors
- Patent Title (中): 筛选G蛋白偶联受体结合配偶体的方法
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Application No.: US14255939Application Date: 2014-04-17
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Publication No.: US09260505B2Publication Date: 2016-02-16
- Inventor: Malcolm Peter Weir , Fiona Hamilton Marshall
- Applicant: Heptares Therapeutics Limited
- Applicant Address: GB Herfordshire
- Assignee: Heptares Therapeutics Limited
- Current Assignee: Heptares Therapeutics Limited
- Current Assignee Address: GB Herfordshire
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: GB0724860.2 20071220
- Main IPC: C07K14/705
- IPC: C07K14/705 ; G01N33/566 ; G01N33/543
Abstract:
A method of producing a conformational specific binding partner of a GPCR, the method comprising: a) providing a mutant GPCR of a parent GPCR, wherein the mutant GPCR has increased stability in a particular conformation relative to the parent GPCR; b) providing a test compound; c) determining whether the test compound binds to the mutant GPCR when residing in a particular conformation; and d) isolating a test compound that binds to the mutant GPCR when residing in the particular formation. Methods of producing GPCRs with increased stability relative to a parent GPCR are also disclosed.
Public/Granted literature
- US20140316116A1 METHODS FOR SCREENING FOR BINDING PARTNERS OF G-PROTEIN COUPLED RECEPTORS Public/Granted day:2014-10-23
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