A method includes generating higher resolution image data based on undersampled higher resolution projection data and incomplete lower resolution projection data. The undersampled higher resolution projection data and the incomplete lower resolution projection data are acquired during different acquisition intervals of the same scan. A system includes a radiation source configured to alternately modulate emission radiation flux between higher and lower fluxes during different integration periods of a scan, a detector array configured to alternately switch detector pixel multiplexing between higher and lower resolutions in coordination with modulation of the fluxes, and a reconstructor configured to reconstruct higher resolution image data based on projection data corresponding to undersampled higher resolution projection data and incomplete lower resolution projection data.