A LED driving control circuit for controlling a power switch in a LED power supply includes: a feedback circuit coupled to a LED load and generating a feedback signal indicative of an output voltage of the LED power supply; an enabling circuit generating an enable signal according to the feedback signal, a first reference signal and a PWM dimming signal, wherein when the feedback signal is higher than the first reference signal, the enable signal synchronizes with the PWM dimming signal, and when the feedback signal is lower than the first reference signal, the duty cycle of the enable signal is higher than the duty cycle of the PWM dimming signal; and a feedback loop control circuit generating a control signal for controlling the power switch according to the feedback signal only when the enable signal is in an active state.