Systems and methods for producing a product gas are provided. In one embodiment, a plurality of gas separation assemblies separate adsorbable components from a gas source using a plurality of micro-pumps to create gas flow through the gas separation assemblies. Various embodiments include implementation of various pressure swing adsorbtion (PSA), vacuum swing adsorbtion (VSA), and vacuum pressure swing adsorbtion (VPSA) systems utilizing the gas separation assemblies with micro-pumps. In other embodiments, micro-pumps and micro-pump assemblies are arranged in various configurations capable of providing a range of pressures and flow rates.