Invention Grant
US09266827B2 Bicyclic sulfone compounds for inhibition of RORgamma activity and the treatment of disease
有权
用于抑制RORGAMMA活性和治疗疾病的双环砜化合物
- Patent Title: Bicyclic sulfone compounds for inhibition of RORgamma activity and the treatment of disease
- Patent Title (中): 用于抑制RORGAMMA活性和治疗疾病的双环砜化合物
-
Application No.: US14398068Application Date: 2013-05-03
-
Publication No.: US09266827B2Publication Date: 2016-02-23
- Inventor: Thomas D. Aicher , Kenneth Jay Barr , Vladimir Simov , William D. Thomas , Peter L. Toogood , Chad A. Van Huis
- Applicant: Merck Sharp & Dohme Corp. , Lycera Corporation
- Applicant Address: US NJ Rahway US MI Ann Arbor
- Assignee: Merck Sharp & Dohme Corp.,Lycera Corporation
- Current Assignee: Merck Sharp & Dohme Corp.,Lycera Corporation
- Current Assignee Address: US NJ Rahway US MI Ann Arbor
- Agency: Goodwin Procter LLP
- International Application: PCT/US2013/039422 WO 20130503
- International Announcement: WO2013/069588 WO 20131114
- Main IPC: C07D233/72
- IPC: C07D233/72 ; C07D263/22 ; C07D207/12 ; C07C317/40 ; A61K31/10 ; A61K31/16 ; A61K31/47 ; C07C311/30 ; C07D263/44 ; C07D207/27 ; C07D209/52 ; C07D211/96 ; C07D213/82 ; C07D215/38 ; C07D217/22 ; C07D223/16 ; C07D231/18 ; C07D401/12 ; C07D471/04 ; C07D491/052
Abstract:
The invention provides bicyclic sulfone compounds, pharmaceutical compositions, methods of inhibiting RORy activity, reducing the amount of iL-17 in a subject, and treating immune disorders and inflammatory disorders using such bicyclic sulfone compounds. Another aspect of the invention provides a method of treating a subject suffering from a medical disorder. The method comprises administering to the subject a therapeutically effective amount of one or more bicyclic sulfone compounds described herein. In certain other embodiments, the disorder is rheumatoid arthritis.
Public/Granted literature
- US20150126493A1 BICYCLIC SULFONE COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE Public/Granted day:2015-05-07
Information query
