Invention Grant
- Patent Title: Substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs as histone demethylase inhibitors
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Application No.: US13921895Application Date: 2013-06-19
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Publication No.: US09266838B2Publication Date: 2016-02-23
- Inventor: Hariprasad Vankayalapati , Venkataswamy Sorna , Steven L. Warner , Bret Stephens , David J. Bearss , Sunil Sharma
- Applicant: Hariprasad Vankayalapati , Venkataswamy Sorna , Steven L. Warner , Bret Stephens , David J. Bearss , Sunil Sharma
- Applicant Address: US UT Salt Lake City
- Assignee: University of Utah Research Foundation
- Current Assignee: University of Utah Research Foundation
- Current Assignee Address: US UT Salt Lake City
- Agency: Wood, Phillips, Katz, Clark & Mortimer
- Main IPC: C07D231/12
- IPC: C07D231/12 ; C07C251/86 ; C07C311/16 ; C07C311/37 ; C07D207/48 ; C07D213/61 ; C07D213/71 ; C07D213/53 ; C07D213/81 ; C07D295/26
Abstract:
In one aspect, the invention relates to substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Public/Granted literature
- US20140163017A1 SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE)BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS Public/Granted day:2014-06-12
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