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Invention Grant
US09266872B2 2-hydroxyarylamide derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating cancer containing same as active ingredient 有权
2-羟基芳基酰胺衍生物或其药学上可接受的盐，其制备方法和用于预防或治疗含有其的活性成分的癌症的药物组合物

2-hydroxyarylamide derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating cancer containing same as active ingredient
Abstract:
The present invention relates to a 2-hydroxyarylamide derivative or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The 2-hydroxyarylamide derivative prepared by the present invention is excellent in the inhibition of the activity of TMPRSS4 serine protease and the suppression of the infiltration of TMPRSS4-expressed cancer cells, and thus can be useful as a composition for preventing or treating cancer by inhibiting TMPRSS4 over-expressed in cancer cells, particularly, colorectal cancer, lung cancer, breast cancer, prostate cancer, ovarian cancer, pancreatic cancer, or stomach cancer cells.
Abstract(Chinese):

本发明涉及2-羟基芳基酰胺衍生物或其药学上可接受的盐，其制备方法和用于预防或治疗癌症的药物组合物，其包含其作为活性成分。 通过本发明制备的2-羟基芳基酰胺衍生物对TMPRSS4丝氨酸蛋白酶的活性的抑制和TMPRSS4表达的癌细胞的浸润的抑制是优异的，因此可以用作通过抑制来预防或治疗癌症的组合物 TMPRSS4在癌细胞，特别是结肠直肠癌，肺癌，乳腺癌，前列腺癌，卵巢癌，胰腺癌或胃癌细胞中过度表达。

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