Invention Grant
US09266890B2 Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
有权
嘧啶二氮杂酮激酶支架化合物和治疗疾病的方法
- Patent Title: Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
- Patent Title (中): 嘧啶二氮杂酮激酶支架化合物和治疗疾病的方法
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Application No.: US13143505Application Date: 2010-01-06
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Publication No.: US09266890B2Publication Date: 2016-02-23
- Inventor: Nathanael S. Gray , Xianming Deng , Nicholas P. Kwiatkowski
- Applicant: Nathanael S. Gray , Xianming Deng , Nicholas P. Kwiatkowski
- Applicant Address: US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.
- Agent Peter F. Corless, Esq.; Daniel W. Clarke
- International Application: PCT/US2010/000050 WO 20100106
- International Announcement: WO2010/080712 WO 20100715
- Main IPC: C07D401/12
- IPC: C07D401/12 ; C07D401/14 ; C07D487/04 ; C07D471/14 ; C07D487/14 ; C07D491/14 ; C07D495/14 ; C07D498/04 ; C07D513/04
Abstract:
The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), polo kinase 1, 2, 3, or 4, Ack1, Ack2, AbI, DCAMKL1, ABL1, AbI mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS 1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, AxI, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.
Public/Granted literature
- US20120040961A1 PYRIMIDO-DIAZEPINONE KINASE SCAFFOLD COMPOUNDS AND METHODS OF TREATING DISORDERS Public/Granted day:2012-02-16
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