Invention Grant
US09266904B2 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
有权
6-桥连杂芳基二氢嘧啶用于治疗和预防乙型肝炎病毒感染
- Patent Title: 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection
- Patent Title (中): 6-桥连杂芳基二氢嘧啶用于治疗和预防乙型肝炎病毒感染
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Application No.: US14279716Application Date: 2014-05-16
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Publication No.: US09266904B2Publication Date: 2016-02-23
- Inventor: Lei Guo , Taishan Hu , Yimin Hu , Buelent Kocer , Buyu Kou , Gangqin Li , Xianfeng Lin , Haixia Liu , Hong Shen , Houguang Shi , Guolong Wu , Zhisen Zhang , Mingwei Zhou , Wei Zhu
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Nutley
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agency: Genentech, Inc.
- Priority: WOPCT/CN2013/075815 20130517; WOPCT/CN2014/075392 20140415
- Main IPC: A61K31/506
- IPC: A61K31/506 ; C07D498/08 ; C07D417/14 ; C07D498/18 ; C07D491/08 ; C07D487/08 ; C07D513/08 ; C07D498/20 ; C07D453/06 ; C07D471/08 ; C07D491/18
Abstract:
The invention provides novel compounds having the general formula: wherein R1, R2, R3 and R4 are as defined in the description and in the claims, as well as or pharmaceutically acceptable salts, or tautomerism isomers, or enantiomers, or diastereomers thereof. The invention also contains compositions including the compounds and methods of using the compounds.
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