Invention Grant
US09266954B2 Methods for modulating D1-D2 dopamine receptor coupling and function
有权
调节D1-D2多巴胺受体偶联和功能的方法
- Patent Title: Methods for modulating D1-D2 dopamine receptor coupling and function
- Patent Title (中): 调节D1-D2多巴胺受体偶联和功能的方法
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Application No.: US13862010Application Date: 2013-04-12
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Publication No.: US09266954B2Publication Date: 2016-02-23
- Inventor: Fang Liu , Lin Pei
- Applicant: Centre for Addiction and Mental Health
- Applicant Address: CA Toronto, Ontario
- Assignee: Centre for Addiction and Mental Health
- Current Assignee: Centre for Addiction and Mental Health
- Current Assignee Address: CA Toronto, Ontario
- Agency: Brooks Kushman P.C.
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K14/705 ; C07K14/47 ; A61K38/00
Abstract:
The present invention provides for prevention and/or treatment of neurological or neuropsychiatric disorders involving abnormal D1-D2 dopamine receptor coupling and/or activation. Methods and agents are provided for modulating dopamine receptor function arising from D1-D2 coupling and/or activation. Agents of the present invention include fragments of D2 receptor or D1 receptor that can disrupt D1-D2 coupling.
Public/Granted literature
- US20130202600A1 Polypeptides And Methods For Modulating D1-D2 Dopamine Receptor Interaction And Function Public/Granted day:2013-08-08
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