Invention Grant
- Patent Title: Modulation of phospholipase D for the treatment of neurodegenerative disorders
- Patent Title (中): 调节磷脂酶D用于治疗神经变性疾病
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Application No.: US13305422Application Date: 2011-11-28
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Publication No.: US09267122B2Publication Date: 2016-02-23
- Inventor: Gilbert DiPaolo , Tae-Wan Kim , Tiago Gil Oliveira
- Applicant: Gilbert DiPaolo , Tae-Wan Kim , Tiago Gil Oliveira
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Baker Botts L.L.P.
- Main IPC: A61K31/445
- IPC: A61K31/445 ; A61K31/415 ; A61K31/05 ; C12N9/20 ; A61K31/454 ; A61K31/4709 ; G01N33/92
Abstract:
The present invention relates to methods of treating neurodegenerative diseases comprising administering, to a subject in need of such treatment, one or more agent that inhibits or reduces the action, including the catalytic activity, of an enzyme of the phospholipase D family, such as phospholipase D1 and/or phospholipase D2. The present invention also relates to cell-based assays which may be used to identify agents that inhibit or reduce the activity of enzymes of the phospholipase D family and that may be used in the treatment of neurodegenerative diseases.
Public/Granted literature
- US20120178719A1 MODULATION OF PHOSPHOLIPASE D FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS Public/Granted day:2012-07-12
Information query
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