Invention Grant
- Patent Title: DNA polymerases with increased 3'-mismatch discrimination
- Patent Title (中): 具有增加的3'-不匹配鉴别的DNA聚合酶
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Application No.: US14228625Application Date: 2014-03-28
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Publication No.: US09267169B2Publication Date: 2016-02-23
- Inventor: Fred Reichert , Keith Bauer , Thomas W. Myers
- Applicant: Roche Molecular Systems, Inc.
- Applicant Address: US CA Pleasanton
- Assignee: Roche MolecularSystems, Inc.
- Current Assignee: Roche MolecularSystems, Inc.
- Current Assignee Address: US CA Pleasanton
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: C12N9/12
- IPC: C12N9/12 ; C12Q1/68

Abstract:
Disclosed are mutant DNA polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e.g., for production of the mutant DNA polymerases.
Public/Granted literature
- US20140212883A1 DNA POLYMERASES WITH INCREASED 3'-MISMATCH DISCRIMINATION Public/Granted day:2014-07-31
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