Systems and method for monitoring a workstation region of a manufacturing line are provided. In one example, depth image data is received from one or more depth cameras trained on the workstation region, with the data comprising a temporal sequence of images of an operator. Using the depth image data, a series of movements of the operator is tracked in 3D space of the workstation region. Operational status data is received from the manufacturing line indicating the manufacturing line is operating. Using the series of movements, the operator is determined to be within a predetermined distance of a hazard. In response, a command is issued to the manufacturing line to cease operating.