Methods and systems for encoding frames while maintaining bounded running disparity, including: encoding the headers of the frames utilizing a first line-code; selecting the first line-code and a second line code for encoding first and second payloads of first and second frames, respectively, based on first and second data types of first and second data comprised in the first and second payloads, respectively; encoding the first and second payloads utilizing the first and second line-codes, respectively; and transmitting the first and second frames over a communication channel characterized by first and second channel conditions, respectively. The second line-code has a minimal Hamming distance lower than that of the first line-code, and the differences between the first and second channel conditions are not enough for selecting the second line-code instead of the first line-code for encoding the second payload.