A system for stapling tissue includes a stapling head and a control unit. The stapling head includes an endoscope receiving lumen extending therethrough and first and second jaws movable with respect to one another between a tissue receiving configuration and a tissue stapling configuration. The first jaw includes a staple firing mechanism and the second jaw includes a staple forming surface. The stapling head further includes gross and fine movement mechanisms controlling gross and fine movements, respectively, of one of the first and second jaws relative to the other of the first and second jaws. The control unit includes a first actuator controlling the gross and fine movement mechanisms and a second actuator operating the stapling mechanism.