A composition for cleaning and sanitizing dental appliances and dentures having at least one of anti-viral, anti-fungal, antibacterial, germicidal, and anti-microbial properties and comprising (a) a surfactant system having a quaternary amine as a first component and a nonionic surfactant as a second component, (b) peppermint oil, (c) a quaternary salt additive, (d) propolis resin extract, (e) antibiotic additive, and (f) Triclosan.