Invention Grant
US09271936B2 Method for forming mesoporous silica nanoparticles, mesoporous silica nanoparticles, and applications thereof
有权
形成介孔二氧化硅纳米粒子,介孔二氧化硅纳米粒子的方法及其应用
- Patent Title: Method for forming mesoporous silica nanoparticles, mesoporous silica nanoparticles, and applications thereof
- Patent Title (中): 形成介孔二氧化硅纳米粒子,介孔二氧化硅纳米粒子的方法及其应用
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Application No.: US12382041Application Date: 2009-03-06
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Publication No.: US09271936B2Publication Date: 2016-03-01
- Inventor: Philip R. DeShong , Michael R. Zachariah , Peter DeMuth , Anand Prakash , Charles Luckett , Douglas Stephen English
- Applicant: Philip R. DeShong , Michael R. Zachariah , Peter DeMuth , Anand Prakash , Charles Luckett , Douglas Stephen English
- Applicant Address: US MD College Park
- Assignee: UNIVERSITY OF MARYLAND
- Current Assignee: UNIVERSITY OF MARYLAND
- Current Assignee Address: US MD College Park
- Agency: Squire Patton Boggs (US) LLP
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K31/704 ; A61K47/48 ; B82Y5/00

Abstract:
A method for synthesizing a mesoporous silica nanoparticle, a mesoporous silica nanoparticle, and applications thereof are provided. The method includes fractionating a mesoporous silica nanoparticle suspension to produce size-fractionated mesoporous silica nanoparticle. The method further includes etching the size-fractionated mesoporous silica nanoparticle to produce synthesized mesoporous silica nanoparticle having a hollow, porous morphology configured to receive one of a therapeutic agent and an imaging material. The etching includes differential etching of silica from areas of low polymeric density within the mesoporous silica nanoparticle and re-depositing of the silica in areas of higher polymeric density existing near the surface of the mesoporous silica nanoparticle. A target material is loaded into the synthesized mesoporous silica nanoparticle and a controlled released of the target material is provided by decreasing the physiological pH of the surface of the mesoporous silica nanoparticle.
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