Invention Grant
- Patent Title: Process for detergent-free production of outer membrane vesicles of a gram-negative bacterium
- Patent Title (中): 无菌生产革兰氏阴性细菌外膜囊泡的方法
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Application No.: US14131279Application Date: 2012-07-05
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Publication No.: US09272006B2Publication Date: 2016-03-01
- Inventor: Bas Van De Waterbeemd , Leonardus Aldolfus Van Der Pol
- Applicant: Bas Van De Waterbeemd , Leonardus Aldolfus Van Der Pol
- Applicant Address: NL The Hague
- Assignee: DE STAAT DER NEDERLANDEN, VERT. DOOR DE MINISTER VAN VWS MINISTERIE VAN VOLKSGEZONDHEID, WELZIJN EN SPORT
- Current Assignee: DE STAAT DER NEDERLANDEN, VERT. DOOR DE MINISTER VAN VWS MINISTERIE VAN VOLKSGEZONDHEID, WELZIJN EN SPORT
- Current Assignee Address: NL The Hague
- Agency: Browdy and Neimark, PLLC
- Priority: EP11173085 20110707
- International Application: PCT/NL2012/050478 WO 20120705
- International Announcement: WO2013/006055 WO 20130110
- Main IPC: C12N1/00
- IPC: C12N1/00 ; A61K35/74 ; A61K39/095 ; A61K39/00
Abstract:
The present invention relates to the fields of medical microbiology and vaccines. In particular the invention relates to a process for detergent-free preparation of outer membrane vesicles (OMV) of Gram negative bacteria for use in vaccines, to OMV obtainable by said process, and to a pharmaceutical composition comprising such OMV. The present invention further relates to the use of OMV of the present invention as a medicament in particular for use in a method for eliciting an immune response.
Public/Granted literature
- US20140147469A1 PROCESS FOR DETERGENT-FREE PRODUCTION OF OUTER MEMBRANE VESICLES OF A GRAM-NEGATIVE BACTERIUM Public/Granted day:2014-05-29
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