Invention Grant
- Patent Title: IFN-beta compositions, preparation methods and uses thereof
- Patent Title (中): IFN-β组合物，其制备方法和用途
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Application No.: US14118757Application Date: 2012-05-16
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Publication No.: US09272020B2Publication Date: 2016-03-01
- Inventor: Daniel Leblanc , Evert Nicolaas Lamme , Helen Gabriela Baldascini , Joel Richard , Frederic Checot , You-Ping Chan , Roger Kravtzoff , Gauthier Pouliquen
- Applicant: Daniel Leblanc , Evert Nicolaas Lamme , Helen Gabriela Baldascini , Joel Richard , Frederic Checot , You-Ping Chan , Roger Kravtzoff , Gauthier Pouliquen
- Applicant Address: CH Aubonne
- Assignee: ARES TRADING S.A.
- Current Assignee: ARES TRADING S.A.
- Current Assignee Address: CH Aubonne
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: EP11305617 20110520
- International Application: PCT/EP2012/059086 WO 20120516
- International Announcement: WO2012/159945 WO 20121129
- Main IPC: A61K38/21
- IPC: A61K38/21 ; A61K9/00 ; A61K47/34 ; A61K47/36 ; A61K9/20 ; A61K9/19 ; A61K47/42
Abstract:
The present invention pertains to interferon-beta (IFN-beta) compositions comprising interferon-beta and a grafted poly(glutamic acid) polymer having an average molecular weight between 26,000 and 40,000 g/mol, grafted with alpha-tocopherol substituents, the average molar grafting ratio being 4.5-5.5 moles %, the weight/weight ratio between said grafted poly(glutamic acid) polymer and IFN-beta being between 24 and 125. The present invention also pertains to the preparation methods of such compositions and their application to obtain therapeutic compositions in dosage unit form delivering IFN-beta over an extended period of time.
Public/Granted literature
- US20140105858A1 IFN-BETA COMPOSITIONS, PREPARATION METHODS AND USES THEREOF Public/Granted day:2014-04-17
Information query
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