Invention Grant
US09272024B2 Compositions, comprising improved IL-12 genetic constructs and vaccines, immunotherapeutics and methods of using the same
有权
组合物，包括改进的IL-12遗传构建体和疫苗，免疫治疗剂及其使用方法
- Patent Title: Compositions, comprising improved IL-12 genetic constructs and vaccines, immunotherapeutics and methods of using the same
- Patent Title (中): 组合物，包括改进的IL-12遗传构建体和疫苗，免疫治疗剂及其使用方法
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Application No.: US14365086Application Date: 2012-12-11
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Publication No.: US09272024B2Publication Date: 2016-03-01
- Inventor: David B. Weiner , Matthew P. Morrow , Jian Yan
- Applicant: The Trustees of the University of Pennsylvania
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Riverside Law LLP
- International Application: PCT/US2012/069017 WO 20121211
- International Announcement: WO2013/090296 WO 20130620
- Main IPC: C12N5/10
- IPC: C12N5/10 ; C07K14/54 ; A61K38/20 ; A61K39/245 ; A61K39/00 ; C12N7/00 ; C12N7/02 ; C12N15/63 ; C12P21/02
Abstract:
Nucleic acid molecules and compositions comprising: a nucleic acid sequence that encodes IL-12 p35 subunit or a functional fragment thereof and/or a nucleic acid sequence that encodes IL-12 p40 subunit or a functional fragment thereof, are disclosed. The nucleic acid molecules and compositions further comprising a nucleic acid sequence that encodes an immunogen are also disclosed. Method of modulating immune response and methods of inducing an immune response against an immunogen are disclosed. Therapeutic and prophylactic vaccination methods are also disclosed.
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