Invention Grant
US09272025B2 Increased T-cell tumor infiltration and eradication of metastases by mutant light
有权
增加T细胞肿瘤浸润，并通过突变光消除转移瘤
- Patent Title: Increased T-cell tumor infiltration and eradication of metastases by mutant light
- Patent Title (中): 增加T细胞肿瘤浸润，并通过突变光消除转移瘤
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Application No.: US12879881Application Date: 2010-09-10
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Publication No.: US09272025B2Publication Date: 2016-03-01
- Inventor: Yang-Xin Fu
- Applicant: Yang-Xin Fu
- Applicant Address: US IL Chicago
- Assignee: The University of Chicago
- Current Assignee: The University of Chicago
- Current Assignee Address: US IL Chicago
- Agency: Barnes & Thornburg LLP
- Agent Alice O. Martin
- Main IPC: C07K14/00
- IPC: C07K14/00 ; A61K39/00 ; C07K14/525 ; C12N7/00
Abstract:
Mutant LIGHT expressed in a tumor environment elicited high levels of chemokines and adhesion molecules, accompanied by massive infiltration of naïve T lymphocytes. Methods and compositions to elicit immune responses against tumors including tumor volume reduction and eradication of metastasis using mutant LIGHT are disclosed.
Public/Granted literature
- US20110014152A1 INCREASED T-CELL TUMOR INFILTRATION AND ERADICATION OF METASTASES BY MUTANT LIGHT Public/Granted day:2011-01-20
Information query
