Invention Grant
- Patent Title: Francisella tularensis live vaccine strains and methods of use
- Patent Title (中): 弗兰西丝亚芽孢杆菌活疫苗株及使用方法
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Application No.: US14480071Application Date: 2014-09-08
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Publication No.: US09272027B1Publication Date: 2016-03-01
- Inventor: Thomas J Lamkin , Roland Saldanha
- Applicant: The United States of America as Represented by the Secretary of the Air Force
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Air Force
- Current Assignee: The United States of America as represented by the Secretary of the Air Force
- Current Assignee Address: US DC Washington
- Agency: AFMCLO/JAZ
- Agent Chastity Whitaker
- Main IPC: A61K39/02
- IPC: A61K39/02 ; A61K49/00 ; A61K48/00 ; C12N15/74 ; A61K39/00
Abstract:
The present invention includes live strain of Francisella tularensis wherein a gene selected from the group consisting of priA and purA is inactivated. The present invention further includes a pharmaceutical composition comprising one or more live strains of Francisella tularensis according to the present invention and a pharmaceutically acceptable carrier. The present invention further includes a method of using one or more live strains of Francisella tularensis according to the present invention to confer immunity against a virulent strain of Francisella tularensis. The method comprises administering an effective amount of one or more live strains of Francisella tularensis according to the present invention or a pharmaceutical composition comprising one or more live Francisella tularensis strains to an animal such that an immune response is produced in the animal.
Public/Granted literature
- US20160067323A1 Francisella tularensis Live Vaccine Strains and Methods of Use Public/Granted day:2016-03-10
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