A twisted string actuator system includes a motor generating rotary motion of a rotor and a twisted string comprised of a pair of cords. One end of the twisted string is attached to the rotor and an opposite end of the twisted string is coupled to a load. The cords are twisted about each other for a first section of the twisted string and untwisted for a second section of the twisted string. A cord guide is fixedly disposed between the cords. The first and second sections of the twisted string are on a first side and second side, respectively, of the cord guide. Rotary motion of the rotor in one direction operates to twist the pair of cords on the first side of the cord guide while pulling a portion of the pair of cords from the second side of the cord guide into the first side.