Apparatus and methods to operate laminar flow control system doors are described. One described example apparatus includes an outboard structure of an aircraft, a first door assembly on a first side of the outboard structure having a first door defining a first opening and a second door assembly on a second side of the outboard structure having a second door defining a second opening. The example apparatus also includes a perforated surface proximate a leading edge of the outboard structure and an actuator disposed in the aircraft. The actuator drives first and second linkages that couple the first and second doors to the actuator. The first and second linkages are to operate the first and second doors, respectively, in an open mode in which the first and second openings create an airflow path between the perforated surface and the first and second openings.