Invention Grant
- Patent Title: Diazeniumdiolate cyclohexyl derivatives
- Patent Title (中): 二氮烯二硫代环己基衍生物
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Application No.: US14115139Application Date: 2012-04-27
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Publication No.: US09272987B2Publication Date: 2016-03-01
- Inventor: Amjad Ali , Michael Man-Chu Lo , Lin Yan
- Applicant: Amjad Ali , Michael Man-Chu Lo , Lin Yan
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Nicole M. Beeler; Catherine D. Fitch
- International Application: PCT/US2012/035318 WO 20120427
- International Announcement: WO2012/151114 WO 20121108
- Main IPC: C07C245/24
- IPC: C07C245/24 ; C07C247/06 ; C07D231/12 ; C07D249/04 ; C07D317/72 ; C07C291/08

Abstract:
A compound having the structure or a pharmaceutically acceptable salt thereof, wherein R6 is hydrogen, —OH, —C1-6alkyl, —OC1-6alkyl, aryl, or halogen, or together with R7, forms an oxo group, or together with R7 and the atom to which they are attached, form a 5-7-membered carbocycle ring or a 5-7-membered heterocyclic ring having 1, 2, or 3 heteroatoms, wherein alkyl and aryl are unsubstituted or independently mono-, di-, or tri-substituted with R14; R7 is hydrogen, C1-6alkyl, —CF3, aryl, —O-aryl, —O—C1-6alkyl, —C(O)OC1-6alkyl, —C(R15R16)OH, a 5-7-membered heteroaryl having 1, 2, 3 or 4 nitrogen atoms, or halogen, or together with R6, forms an oxo group, or together with R6 and the atom to which they are attached, form a 5-7-membered carbocycle ring or a 5-7-membered heterocyclic ring having 1, 2, or 3 heteroatoms wherein alkyl, aryl and heteroaryl are unsubstituted or independently mono-, di- or tri-substituted with R14; R12 is hydrogen, C1-6alkyl, or —(CH2)1-2OH, or together with R13 and the nitrogen atom to which they are attached, form a 4- to 7-membered heterocyclic ring containing one nitrogen atom and 0 or 1 oxygen atoms, wherein said ring is unsubstituted or independently mono-, di- or tri-substituted with halogen or —C1-6alkyl; R13 is —C1-6alkyl or —(CH2)1-2OH, or together with R12 and the nitrogen atom to which they are attached, form a 4- to 7-membered heterocyclic ring containing one nitrogen atom and 0 or 1 oxygen atoms, wherein said ring is unsubstituted or independently mono-, di- or tri-substituted with halogen or —C1-6alkyl.
Public/Granted literature
- US20140088048A1 DIAZENIUMDIOLATE CYCLOHEXYL DERIVATIVES Public/Granted day:2014-03-27
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