Invention Grant
- Patent Title: Dual-acting imidazole antihypertensive agents
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Application No.: US14662722Application Date: 2015-03-19
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Publication No.: US09273008B2Publication Date: 2016-03-01
- Inventor: Seok-Ki Choi , Roland Gendron , Paul R. Fatheree , Robert Murray McKinnell , Brooke Olson
- Applicant: Seok-Ki Choi , Roland Gendron , Paul R. Fatheree , Robert Murray McKinnell , Brooke Olson
- Applicant Address: US CA South San Francisco
- Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah
- Main IPC: A61K31/4164
- IPC: A61K31/4164 ; C07D233/54 ; C07D233/70 ; C07D213/64 ; C07D231/14 ; C07D233/64 ; C07D233/68 ; C07D233/90 ; C07D249/08 ; C07D401/12 ; C07D403/10 ; C07D513/04 ; C07D513/14 ; A61K31/415 ; A61K31/417 ; A61K31/4188 ; A61K31/4196 ; A61K31/4412 ; A61K45/00 ; C07D207/46 ; C07D213/89 ; C07D255/02 ; A61K45/06 ; C07D207/36
Abstract:
The invention is directed to compounds having the formula: wherein: Ar, r, R2-3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Public/Granted literature
- US20150191435A1 DUAL-ACTING IMIDAZOLE ANTIHYPERTENSIVE AGENTS Public/Granted day:2015-07-09
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