Invention Grant
![5-amino[1,4]thiazines as BACE 1 inhibitors](/docs/US/2016-03-01/US09273042B2/abs.jpg.600x600.jpg)
- Patent Title: 5-amino[1,4]thiazines as BACE 1 inhibitors
- Patent Title (中): 5-氨基[1,4]噻嗪作为BACE1抑制剂
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Application No.: US14400448Application Date: 2013-05-21
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Publication No.: US09273042B2Publication Date: 2016-03-01
- Inventor: Hans Hilpert , Thomas Woltering
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Nutley
- Assignee: HOFFMANN-LA ROCHE INC.
- Current Assignee: HOFFMANN-LA ROCHE INC.
- Current Assignee Address: US NJ Nutley
- Priority: EP12169353 20120524
- International Application: PCT/EP2013/060352 WO 20130521
- International Announcement: WO2013/174781 WO 20131128
- Main IPC: C07D417/12
- IPC: C07D417/12
![5-amino[1,4]thiazines as BACE 1 inhibitors](/abs-image/US/2016/03/01/US09273042B2/abs.jpg.150x150.jpg)
Abstract:
The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
Public/Granted literature
- US20150141413A1 5-AMINO[1,4]THIAZINES AS BACE 1 INHIBITORS Public/Granted day:2015-05-21
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