Invention Grant
- Patent Title: Stabilized receptor polypeptides and uses thereof
- Patent Title (中): 稳定受体多肽及其用途
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Application No.: US13775756Application Date: 2013-02-25
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Publication No.: US09273114B2Publication Date: 2016-03-01
- Inventor: Jeonghoon Sun , Lei-Ting Tony Tam , Mark Leo Michaels , Thomas C. Boone , Rohini Deshpande , Yue-Sheng Li , Huiquan Han
- Applicant: Amgen
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agency: Fenwick & West LLP
- Main IPC: C07K14/71
- IPC: C07K14/71 ; C07K14/495
Abstract:
The present invention provides stabilized activin IIB receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the stabilized polypeptides and proteins. Compositions and methods for treating muscle-wasting diseases and metabolic disorders are also provided.
Public/Granted literature
- US20130225484A1 STABILIZED RECEPTOR POLYPEPTIDES AND USES THEREOF Public/Granted day:2013-08-29
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